Absolutely not. The break off stroke abides by exactly the same rules as any other stroke: ball on must be first contacted by White, ball on is the only ball allowed to fall in pocket for legal stroke. All other potential fouls apply exactly the same as normal. Except.........
There is just one rule related to the break off that perhaps you might want to consider a "special" rule because it is different than any other stroke. Care to think about it for a bit? I will skip a few lines to let you think, then give a clue.
Have you ever been waiting for your playing partner to set the Reds for your break off, meanwhile, you set the Baulk colours, and when he is out of the way, you decide to change position of the White and accidentally bump the Green or the Brown with the back of your hand? Foul or not?
In fact, this is the one thing different about the break off stroke....you cannot commit any sort of foul prior to the initial contact of the tip on the White for the opening stroke. Technically, the frame has not yet begun prior to this point so there simply cannot be a foul. Other than that, smash 'em up, play off Black cushion if you like. If you do it just right, you might just pot a Red in a middle and leave position nicely on Black to start your 147. I am not a big fan of this break off myself because it always takes Pink well off spot and Pink sometimes knocks Blue off spot as well. Break building can be tricky right off the bat.
If you are looking to open up the Reds immediately, there is a different break off stroke I quite often use. (To be clear, I usually play a standard safety break off, but hey, sometimes you just want to pot balls!) Requires a good comfort level with a lot of side and consequent swerve, but it makes an interesting start to a frame. I line up White very close to Yellow and play a strong stroke, plenty of top left, aiming at about the fourth Red down the line. White should swerve to barely miss Pink and strike the second Red as full as possible. The reverse side will kill a lot of the speed off the Black cushion while the top should hopefully avoid the in off. White goes off side cushion and wanders back into Baulk between the Yellow and Brown.
Using this break, I pot a Red into the top left pocket perhaps one out of three or four, although I also go in off maybe one of six or seven. The Reds split all apart but stay at the Black end so in off is still pretty safe except against a great long potter. If you pot and end up on a Baulk colour to the middle, you can start a break straight away, but if the pots are bad, you can roll up to Baulk and your opponent is very likely to escape but leave you on Red with them split so far and wide. I don't play against anyone that can run more than a handful of balls at a time anyway so this break off is generally reasonably safe and also definitely quickens the pace of a frame from the start. My opponent figures that I just got lucky that I didn't leave a good Red for him, but in reality, this is usually a pretty safe break off even scattering the Reds so much. Black will be covered as often as not, but you can work Blue until you can get the Black cleaned up. Try it and good luck!